Matthew F. Koff, PhD

Appointments

Assistant Scientist, Research Division, Hospital for Special Surgery

Education

PhD, Biomedical Engineering, Columbia University, 2004
MPhil, Biomedical Engineering, Columbia University, 2003
MS, Biomedical Engineering, Columbia University, 1999
BS, Mechanical Engineering (Pre-med option), The George Washington University, 1997

 

Selected Publications

For more publications, please see the PubMed listing.  

Research Description

Dr. Koff is an Assistant Scientist at the Hospital for Special Surgery, in the Department of Radiology and Imaging – MRI Division. He received a BS in Mechanical Engineering (Pre-Med option) from The George Washington University, and a MS and Ph.D. in Biomedical Engineering from Columbia University. His research work at Columbia University focused on the effects of osteoarthritis on the biomechanics of the thumb carpometacarpal joint. Working with engineers and surgeons, he quantitatively evaluated surgical methods which are commonly used to treat the painful thumb and restore normal joint function.

Dr. Koff completed a post-doctoral fellowship at the Mayo Clinic, focusing on using magnetic resonance imaging (MRI) for quantitative analysis of articular cartilage. He received an NIH RSNA (F32) post-doctoral training grant to use two novel emerging magnetic resonance imaging techniques (dGEMRIC and T2 mapping) to quantitatively assess the stage of osteoarthritis (OA) in the human hip joint. The results of this study will give further insight into the early degenerative changes of the hip may overcome the weaknesses and limitations of traditional OA staging using radiography.

Currently, Dr. Koff works with Dr. Hollis Potter, Chief of MRI continuing to use T2 mapping and T1rho mapping to evaluate the biochemical composition of cartilage, T2* mapping to evaluate meniscal and tendon repair, and novel methods to image around total joint replacements.

Dr. Koff and Dr. Potter are co-PIs on the NIH grant “Evaluation of an MRI Biomarker for Meniscal Repair” (1RC1AR058255). This study will evaluate the ability of a completely noninvasive, quantitative MRI (qMRI) technique, performed at clinically relevant field strengths, to assess meniscal repair and function. The long term objective of this study is to establish a correlation between the non-invasive qMRI T2* mapping of knee meniscus with biomechanical properties and histological appearance of meniscal tissue.

Dr. Koff is a member of the International Society of Magnetic Resonance in Medicine (ISMRM), Orthopaedic Research Society (ORS), and the American Society of Mechanical Engineers (ASME).