Chisa Hidaka, MD

Appointments

Assistant Scientist, Research Division Hospital for Special Surgery

Adjunct Assistant Professor, Genetic Medicine, Weill Medical College of Cornell University

Lecturer, Dance Department, Bernard College of Columbia University

 

Selected Publications

Kiuru M, Solomon J, Ghali B, van der Meulen M, Crystal RG, Hidaka C. Transient Overexpression of Sonic Hedgehog Alters the Architecture and Mechanical Properties of Trabecular Bone J Bone Miner Res 2009 Sep;24(9):1598-607.

Jiang J, Leong NL, Mung JC, Hidaka C, Lu HH. Interaction between Zonal Populations of Articular Chondrocytes Suppresses Chondrocyte Mineralization and this Process is Mediated by PTHrP. Osteoarthritis Cartilage. 2008 Jan;16(1):70-82.

Goodrich LR, Hidaka C, Robbins PD, Evans CH, Nixon AJ. Genetic modification of chondrocytes with insulin-like growth factor-1 enhances cartilage healing in an equine model. J Bone Joint Surg Br. 2007 May;89(5):672-85.

Cheng C, Conte E, Pleshko-Camacho N, Hidaka C. Differences in Matrix Accumulation and Hypertrophy in Superficial and Deep Zone Chondrocytes are Controlled by Bone Morphogenetic Protein. Matix Biol; Matrix Biol. 2007 Sep;26(7):541-53.

Zhu W, Kim J, Cheng C, Rawlins BA, Boachie-Adjei O, Crystal RG, Hidaka C. Noggin regulation of bone morphogenetic protein (BMP) 2/7 heterodimer activity in vitro. Bone. 2006 Jul;39(1):61-71.

Bhargava MM, Hidaka C, Hannafin JA, Doty S, Warren RF. Effects of hepatocyte growth factor and platelet-derived growth factor on the repair of meniscal defects in vitro. In Vitro Cell Dev Biol Anim. 2006 Sep-Oct;41(8-9):305-10

Hidaka, C., Cheng, C., Alexandre, D., Bhargava, M., and Torzilli, P. A. (2006) Maturational Differences in Superficial and Deep Zone Articular Chondrocytes. Cell Tissue Research, 323:127-135.

For more publications, please see the PubMed listing.  

Research Description

The major interest is to use gene therapy to improve connective tissue repair and regeneration. Currently the major focus is to elucidate the molecular mechanisms of post-natal cartilage growth and morphogenesis, in particular the roles of hedgehog signaling and related pathways. Previous studies have examined the use of therapeutic gene transfer to improve cartilage repair, spine fusion and bone formation in a number of translational animal models.